Author Affiliations
Abstract
Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
Photoacoustic (PA) tomography (PAT) breaks the barrier for high-resolution optical imaging in a strong light-scattering medium, having a great potential for both clinical implementation and small animal studies. However, many organs and tissues lack enough PA contrast or even hinder the propagation of PA waves. Therefore, it is challenging to interpret pure PAT images, especially three-dimensional (3D) PA images for deep tissues, without enough structural information. To overcome this limitation, in this study, we integrated PAT with X-ray computed tomography (CT) in a standalone system. PAT provides optical contrast and CT gives anatomical information. We performed agar, tissue phantom, and animal studies, and the results demonstrated that PAT/CT imaging systems can provide accurate spatial registration of important complementary contrasts.
170.5120 Photoacoustic imaging Chinese Optics Letters
2018, 16(12): 121701
1 陕西理工大学 物理与电信工程学院, 陕西 汉中 723001
2 北京大学 工学院生物医学工程系, 北京 100871
为了更形象直观的反映病变组织的位置、大小和形状, 利用高灵敏、大角度接收的多元线性阵列探测器接收光声信号, 并将多元线性阵列探测器进行平面扫描, 得到光声信号的三维数据, 再采用滤波反投影算法将探测到的三维数据直接在整个3D空间进行反投影重建, 得到了模拟血管、铅笔芯和鸡肝的3D重建图像。由实验结果表明, 通过该方法和系统构建的3D图像分辨率较高, 对比度较好, 其x、y、z方向的分辨率分别为0.67、0.34和1 mm。该装置和成像方法将为以后临床病变组织的3D光声成像检测提供一定的技术支持。
医用光学与生物技术 3D光声成像 多元线性阵列探测器 medical optics and biotechnology 3D photoacoustic imaging multi-linear array detector
